Reelin functions beyond neuronal migration: from synaptogenesis to network activity modulation

Reelin, a glycoprotein of the extracellular matrix, has been focus several studies over years, mostly for its role in cell migration. Here we report this molecule and downstream pathways post-mitotic neurons how they contribute to neural circuit assembly, refinement function. Accumulating evidence pointed at major Reelin axonal guidance, synaptogenesis dendritic spine formation. In particular, new points direct targeting target site. addition, recent advances highlight functions modulation synaptic activity, plasticity behavior regulation GABA receptors expression stability. We discuss these findings context neurodevelopmental disorders.